Podophyllin office therapy against condyloma should be abandoned

Podophyllin office therapy against condyloma should be abandoned.

Podophyllin, a crude plant extract with low efficacy, high toxicity, and a serious mutagenicity profile does not comply with the WHO guidelines for plant derived treatments and should be removed from clinical treatment protocols. Home treatment with pharmaceutical products based on podophyllotoxin-the purified, standardised active antiwart ingredient of podophyllin-represents safe and effective...

Should chelation therapy be abandoned ?

Should prostate-specific antigen velocity be abandoned?

P rostate-specific antigen (PSA) is the most widely used biomarker for prostate cancer, but may also be elevated in nonmalignant conditions such as benign prostatic hyperplasia. Studies in the early 1990s suggested that rapid increases in PSA over time—a concept known as PSA velocity (PSAV)—may be useful to distinguish prostate cancer from the generally slower rise in PSA that may be seen in be...

Should preoperative mechanical bowel preparation be abandoned?

The intermediate disturbance hypothesis should be abandoned.

A leading idea about how disturbances and other environmental fluctuations affect species diversity is the intermediate disturbance hypothesis (IDH). The IDH states that diversity of competing species is, or should be expected to be, maximized at intermediate frequencies and/or intensities of disturbance or environmental change. I argue that the IDH has been refuted on both empirical and theore...